SDS Vault Safety Data Sheet Reference

MDI (Methylene Diphenyl Diisocyanate)

CAS: 101-68-8 Category: Industrial ⚠ DANGER
Also known as: Diphenylmethane diisocyanate, MDI, Isonate, Mondur M

Quick Facts

CAS Number101-68-8
Signal WordDANGER
GHS Hazard Classesharmful, health hazard
NFPA RatingHealth: 3 / Flammability: 1 / Reactivity: 1
Common NamesDiphenylmethane diisocyanate, MDI, Isonate, Mondur M
PubChem CID9419

Hazard Summary

⚠ DANGER: Diisocyanate hardener used in polyurethane coatings and foams. OSHA STEL 0.1 ppm ceiling. Respiratory sensitizer — a single high-dose exposure can cause permanent occupational asthma. IDLH 0.02 ppm.

GHS Hazard Pictograms

⚠ Harmful/Irritant ❤️ Health Hazard

Hazard Statements (H-codes)

H315 – Causes skin irritation
H317 – May cause allergic skin reaction
H319 – Causes serious eye irritation
H334 – May cause allergy or asthma symptoms if inhaled
H335 – May cause respiratory irritation
H351 – Suspected of causing cancer

Precautionary Statements (P-codes)

P260 – Do not breathe dust/vapour
P284 – Use respiratory protection
P342+P311 – If respiratory symptoms: Call Poison Control immediately

First Aid Measures (Section 4)

👁 Eye Contact
Flush with water for 15 minutes. Seek immediate medical attention.
🖐 Skin Contact
Wash with soap and water. Remove contaminated clothing. Report sensitization history to physician.
🫁 Inhalation
Remove to fresh air immediately. Seek emergency care. Isocyanate-induced asthma attacks can be severe and delayed.
🫦 Ingestion
Call Poison Control (1-800-222-1222). Seek medical attention.

Storage & Handling

🔒 Storage & Handling: Store sealed in cool, dry area away from moisture, amines, and alcohols. Secondary containment. Moisture causes CO2 evolution and pressure buildup.

PPE Requirements

Full-face supplied-air respirator
Chemical splash goggles
Butyl rubber gloves
Chemical-resistant coveralls
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