SDS Vault Safety Data Sheet Reference

Acetonitrile (Lab Solvent)

CAS: 75-05-8 Category: Solvents ⚠ DANGER
Also known as: Methyl cyanide, Cyanomethane, MeCN, ACN

Quick Facts

CAS Number75-05-8
Signal WordDANGER
GHS Hazard Classesflammable, toxic, harmful
NFPA RatingHealth: 2 / Flammability: 3 / Reactivity: 2
Common NamesMethyl cyanide, Cyanomethane, MeCN, ACN
PubChem CID6342

Hazard Summary

⚠ DANGER: Common HPLC solvent. Metabolizes slowly to cyanide — delayed toxicity means initial symptoms may be mild. Flammable liquid with wide explosive range (3–16%).

GHS Hazard Pictograms

🔥 Flammable ☠ Acutely Toxic ⚠ Harmful/Irritant

Hazard Statements (H-codes)

H225 – Highly flammable liquid and vapour
H302 – Harmful if swallowed
H312 – Harmful in contact with skin
H319 – Causes serious eye irritation
H332 – Harmful if inhaled

Precautionary Statements (P-codes)

P210 – Keep away from heat/ignition
P260 – Do not breathe vapours
P301+P312 – IF SWALLOWED: Call Poison Control

First Aid Measures (Section 4)

👁 Eye Contact
Flush with water for 15 minutes. Seek medical attention.
🖐 Skin Contact
Wash with soap and water. Absorbed through skin — monitor for delayed cyanide symptoms (headache, dizziness, nausea).
🫁 Inhalation
Remove to fresh air. Delayed cyanide toxicity possible. Seek medical evaluation for all significant exposures.
🫦 Ingestion
Call Poison Control (1-800-222-1222) immediately. Treat for potential cyanide toxicity even if initial symptoms are absent.

Storage & Handling

🔒 Storage & Handling: Flammable storage cabinet. Incompatible with strong acids, bases, and oxidizers.

PPE Requirements

Chemical goggles
Nitrile gloves
Organic vapour/cyanide respirator in poor ventilation
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